Biofilms role in today’s health.

What is a BioFilm?

Biofilms are little communities of organisms in your body that join forces to avoid elimination. The protective coating they form is officially called a polymer matrix, which is like a “force field” or barrier that keeps drugs like antibiotics, antivirals, antifungals or any other antimicrobial from being effective in removing them. They are a huge concern in the medical community at the moment, however, many patients and physicians don’t even know about them. 

Biofilms are capable of adapting to many environments and thus can be found in all parts of the body. These areas include teeth, sinuses, tonsils, eustachian tubes of the middle ear and the intestines. Biofilms in the intestines can lead to chronic digestive and allergic responses often seen in difficult cases.

Immune Imbalance

The immune system is responsible for attacking, controlling and eliminating biofilms. In healthy individuals, this happens regularly, however, in susceptible individuals, biofilms can take hold and begin to wreak havoc on the whole body, specifically the immune system.

T-Cells

By launching an attack on the biofilms via immune cells (macrophages, natural killer cells, cytotoxic T cells and T lymphocytes) the body also creates a significant amount of inflammation. What happens then is the immune system shifts to what we call a TH2 dominant state with the TH1 cells in a lowered state. By shifting to TH2 dominance, the body is then unable to launch a full TH1 attack and eliminate the biofilm. It is most likely constantly battling the biofilm, but simply doesn’t have enough strength to eliminate it.

A TH2 dominant state is very common in many conditions. The TH2 dominant state is what we find in many people with traditional allergies. If you have an overactive TH2 dominant system, you will tend to have food allergies and sensitivities or airborne allergies and an increase in histamine release. This may even be confused with histamine intolerance. Some things that may push someone towards TH2 dominance include genetic predisposition, toxic substances and heavy metal exposure.

Biofilms and the Gut

One of the reasons you may have biofilms in the first place is due to early exposure to antibiotics. There are actually good biofilms that can be destroyed by antibiotics. These good biofilms and healthy gut flora provide a natural type of defense to foreign invaders.   Without the good biofilms as a defense mechanism, bad biofilms can proliferate and destroy the gut lining and increase permeability, a term commonly coined as “leaky gut”. With leaky gut, the intestinal barrier is compromised and allows substances to move into the bloodstream. By allowing different substances into the bloodstream, inflammation begins and things such as food allergies and sensitivities eventually alter the health of the immune system. The leaky gut will lead us to a TH2 dominant state as I mentioned above. Leaky gut also can slow down digestion, decrease toxin clearance and initiate proinflammatory chemicals.

Clinical Research

Research in gut health and immune system responses to permeable gut linings are revealing significantly new understandings into how these natural defenses work. This new research also helps us learn how to support the body’s ability to maintain a balanced and healthy gut flora.  

Dr. Paul S. Anderson is on the leading forefront of biofilm research and education.  

We are excited to announce that we have received exclusive access to Dr. Paul Anderson’s webinar on BioFilms, worth $59.00 – and are offering it to you for FREE!

Visit this page for more information.

Good health to you!

Danielle Baumgart, President

Priority One Nutritional Supplements Inc.

Magnesium Orotate recently featured in Readers Digest article

Dr. John Nowicki
Orotic acid is a biochemical substance made by all living cells. The mineral salts of orotic acid, called orotates, are used by plants and animals to form RNA and DNA. Perhaps the biggest proponent in the use of orotates was Dr. Hans Nieper, a German physician whose treatments were denounced by many American physicians. Nieper believed orotates were far superior in their ability to carry molecules across cell membranes, producing higher concentrations of minerals in the cell.
Dr. Nieper used orotates as treatments for many conditions. During his lifetime, Dr. Nieper was often ignored and criticized for his use of oratates. Recent research, however, has confirmed that for certain conditions, minerals bound to oratic acid are not only beneficial, but may be superior in their bioavailability and effectiveness.
Magnesium orotate is a mineral salt that is normally found in lesser amounts in all living things.
Magnesium is essential for the proper functioning of the brain, nerves, and muscles. It acts as a smooth muscle relaxant, promotes healthy glucose metabolism, and acts as a cofactor to enzymes in many biochemical reactions.1
It is essential for cellular energy production, nerve conduction, cardiac function, bone mineralization, and muscle relaxation. Magnesium may be beneficial in reducing occasional anxiety, promoting sleep, and decreasing muscle tension and occasional pain.
A 1998 study showed that triathletes who supplemented with magnesium orotate had improved glucose utilization and a reduced stress response without affecting competitive potential. This translated into improved swimming, cycling, and running times in the magnesium orotate group compared with the controls.2 Competitive athletes have also used magnesium orotate to improve endurance.
Many studies have been performed examining the role of magnesium orotate in cardiovascular health. Magnesium orotate has been shown to improve endothelial function, and exercise tolerance, studies have shown favorable effects of oral magnesium orotate to left ventricular function and exercise tolerance,4 as well as increasing survival rate and improving clinical symptoms and patient’s quality of life 3.
It is believed that magnesium orotate improves the energy status of heart muscle by stimulating the synthesis of glycogen and ATP.5
Dr. Carolyn Dean

Dr. Carolyn Dean, author of “The Magnesium Miracle,” asserts that changes in our diets and the way in which food is processed have left many of us with deficient levels of the nutrient magnesium. Magnesium orotate is one compound that has been used effectively to treat magnesium deficiency and its associated symptoms. In magnesium orotate, magnesium is bound to oratic acid.  the mineral is absorbed very efficiently by your body. Magnesium orotate can be used to improve sleep, as it inhibits some “stress” hormones like adrenalin.  Magnesium orotate supports good hydration of your body by helping to regulate the flow of sodium and potassium through your cells.

“Magnesium deficiency is one of the most underrated minerals, but it’s involved in literally hundreds of your body’s functions. Pay attention to it, and your body will thank you.” According to author: Alexandra Whiitaker
Magnesium Orotate recently featured in Readers Digest article Cheaper and Safer Than Prescription Drugs
Magnesium orotate is magnesium salt bound to orotic acid. It’s the most easily absorbed form of magnesium and passes easily through the cells in your body, especially when compared with other types of magnesium. If you need magnesium supplementation, as most people do because the standard American diet often lacks foods high in magnesium, magnesium orotate from Priority One is the most bioavailable Magnesium Orotate on the market get your bottle today!
1 Marz, Russell. Medical Nutrition from Marz. Portland: Omni-Press, 1997.
2 Golf SW, Bender S, Grüttner J. On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther. 1998 Sep; 12 Suppl 2:197-202.
3 Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). Int J Cardiol. 2009 May 1;134(1):145-7.
4 Geiss KR, Stergiou N, Jester, Neuenfeld HU, Jester HG. Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:197-202.
5 Classen, HG. Magnesium orotate–experimental and clinical evidence. Rom J Intern Med. 2004; 42(3):491-501.

DHEA

DHEA or dehydroepiandrosterone is a prohormone produced in the adrenal glands and testes. As a prohormone, it can be converted into testosterone and/or estrogens in various peripheral target tissues throughout the body.

Blood sample for DHEA (dehydroepiandrosterone) hormone test
Blood sample for DHEA (dehydroepiandrosterone) hormone test

However, plasma DHEA decreases about 80% between the ages of 25 and 75 years. This is determined by measuring the blood marker for measuring DHEA, called DHEA-S. DHEA-S levels were found to be significantly lower in men with aging male symptoms such as decreased sexual desire and dysfunction cites a study involving 348 male patients.

DHEA supplementation in older men and women demonstrated in a double-blind, placebo-controlled study were 280 healthy men and women ages 69 to 79 were given 50 mg of DHEA or placebo daily for a year. The results were that supplementation reestablished “young” concentrations of DHEA-S and modestly increase testosterone and estradiol levels. The authors of this study concluded “that 50 mg of DHEA administration over one year normalized some effects of aging but does not create “Supermen or Superwomen”

As a prohormone, supplementation with DHEA appears to be relatively safe and effective. Nevertheless, there is value in assessing blood serum DHEA-S levels for individuals planning to use DHEA regulate prick. There is a particularly important population younger than 40 years of age who are more likely to have naturally higher levels of DHEA.

References: Journal of Endocrinology. 2005; 187:169-196.; Aging 2011; 3:533-542.; Urology 2005; 66:597-601; J Clin Endocrinol Metab, September 2013, 98(9):3615–3626.