Bio-Candida Care

Candida albicans is a commensal fungus that is usually acquired during neonatal life. As a commensal fungus of the gastrointestinal tract it normally does not cause damage to the host. However, it can cause opportunistic infections when an individual is medically or immune compromised. These opportunistic infections can be anything from mucosal to systemic candidiasis which can be life threatening. In fact, candidiasis is the third-to-fouth most common hospital-acquired infection both in the US and worldwide. One of the reasons treatment is complicated and there is a high mortality rate is because these infections are often associated with biofilms.

Biofilms are extremely hard to eradicate. Cells within the biofilm grow as a community and create a protective matrix around them making it harder for the immune system to respond to the infection. To make it worse, the cells that disperse from the biofilm matrix tend to have increased virulence. Studies show an increased pathogenicity when looking at host-biofilm interaction for Candida albicans. The biofilm is able to influence aspects of the innate immune response by decreasing the migration, phagocytosis and production of cytokines by the immune system. Meanwhile, the immune cells in the presence of biofilms tend to promote a thicker biofilm layer that is harder to penetrate. 

Even though the biofilm does a good job of protecting Candida albicans from the immune system, the Candida cells that have developed inside the biofilm are able to detach and spread to the bloodstream causing systemic candidiasis. Environmental triggers such as pH and carbon source can lead to this process of yeast-like cells budding from the biofilm, detaching and disseminating through the bloodstream. Because antifungal resistance is an ever present issue and there is an expanding population of medically and immunocompromised individuals who are at a high risk for infection it is imperative to have alternative forms of support for preventing and eliminating fungal overgrowth. 

Priority One Vitamins has partnered with Dr. Mona Morstein to develop Bio-Candida Care, a new formula specifically for fungal overgrowth in the gut. Bio-Candida Care was designed to support a healthy gut biome while at the same time preventing biofilm formation, breaking down existing biofilms and inhibiting the growth and proliferation of Candida albicans. It includes calcium undecylenate since undecylenic acid has the ability to inhibit biofilm formation and can also cause cell walls to atrophy. Sodium caprylate is used because it also has the ability to cause cell wall breakdown, loss of organelle function, and inhibits the budding and growth of Candida albicans. Olive leaf has antimicrobial and antifungal properties supporting both the elimination of Candida and preventing regrowth. Oregano oil and thyme oil are wonderful antimicrobials included to support a healthy immune response.

Calcium (as calcium undecylenate): 54 mg – Undecylenic acid inhibits biofilm formation of Candida albicans. Studies show that it can also cause cell walls to atrophy. 

Sodium (as sodium caprylate): 79 mg – Sodium caprylate inhibits the budding of Candida albicans and causes loss of function of cell organelles including the mitochondria. It has also been shown to decrease cellular integrity resulting in the breakdown of their cell walls.  

Olive (leaf): 250mg – Contains a polyphenol called oleuropein. Oleuropein has antimicrobial and antifungal properties supporting both the elimination of Candida and  preventing regrowth. 

Oregano Oil: 250 mg – Oregano is an herb with antimicrobial properties. Because of its broad spectrum antimicrobial activity it can be used for bacterial and fungal infections. 

Thyme oil: 200 mg – an antimicrobial herb that is often used for gastrointestinal conditions. Thyme’s antimicrobial properties have been shown to include antifungal effects against Candida.  

References:

Adams, J N, et al., Effects of Sodium Caprylate on Candida Albicans. I. Influence of Concentration on Ultrastructure https://pubmed.ncbi.nlm.nih.gov/14066435/

Frontiers in Microbiology https://www.frontiersin.org/articles/10.3389/fmicb.2020.01437/full

Gaby, Alan Nutritional Medicine

Marciano & Vizniak, Botanical Medicine 

Nature.com https://www.nature.com/articles/npjbiofilms201512

Shi, Dongmai, et al. Antifungal Effects of Undecylenic Acid on the Biofilm Formation of Candida Albicans https://pubmed.ncbi.nlm.nih.gov/26902505/

New Kiwi Kleanse 20% OFF

Priority One is excited to present our newest chewable formula, Kiwi Kleanse!

Kiwi Kleanse is a delicious natural kiwifruit-flavored chewable tablet containing Actazin & marshmallow root.

This new exclusive formula is designed to provide easy-to-administer relief for occasional constipation including in children and pregnant women.  The active ingredient Actazin is a non-GMO, cold-pressed kiwifruit powder sourced from New Zealand.  It contains a unique combination of bioactive nutrients that effectively and gently support the digestive and laxation processes. 

These active components are clinically shown to increase bowel movements in healthy individuals.  Additionally, Actazin contains polyphenols, which are micronutrients known for their wide range of health benefits, including the potential to reduce temporary mucusal inflammation caused by poor digestion. The kiwi enzyme, actanidin, is a proteolytic enzyme that breaks down proteins, which may help to reduce bloating and abdominal discomfort. 

Kiwi Kleanse includes prebiotic properties, which support the growth of beneficial gut bacteria.  These bacteria, when allowed to multiply, produce essential short chain fatty acids that provide metabolic fuel for the colon.

Research on the levels of vitamin A and C in the kiwi fiber have been shown to have an anti-inflammatory effect, which may contribute to the gut’s motility & ability to keep things moving. Kiwi fiber is a source of both soluble and insoluble fiber with the ability to increase water retention, which provides for softer and bulkier stools. 

The ingredient of marshmallow root is noted for it’s ability to produce natural mucilage to support and soothe the digestive tract. 

As a special offer to our loyal customers, we are offering 20% off of Kiwi Kleanse in the month of November. Please use code “kiwi20” to receive this offer on your website or phone order!

https://pdfs.semanticscholar.org/f181/dd3731665f73bfc7f75fdac7aa0472957bfb.pdf

November Product Spotlight – Reflux Soothe and Licorice Plus

This month we are featuring Reflux Soothe and Licorice Plus

Licorice Plus provides soothing support for the gastrointestinal tract in a natural licorice flavored chewable tablet.*

Designed to stimulate the body s natural protective factors in the gastrointestinal tract providing relief for occasional stomach discomfort.*

 

 

 

Reflux Soothe is a specialized formulation by Dr. John Hahn that has been designed to provide relief for occasional indigestion.*

Buy two Reflux Soothe, get two Licorice Plus for free!

Just add all items to your cart on our Website, enter the promo code “2for2” and your discount will apply.

 

Also, be entered to win a $100 gift certificate by sharing this special on our Facebook here

 

Priority One Upcoming Events:
December 2018

OANP – Oregon Association of Naturopathic Physicians

December 1st – 2nd, 2018
Theme: 23rd Annual Pharmacy and Ethics Conference “Polypharmacy and Deprescribing: When Less is More”
Location: Portland Waterfront Marriott Hotel
December 8th, 2018
Location: Bastyr Center for Natural Health Clinic
January 2019
January 24th – 27th, 2019
Theme: Advanced Approaches to Complex Infectious Disease
Location: Courtyard Marriott, Kona Beach Hotel, Big Island, HI
Do you have an upcoming event you would like us to attend such as an Open House or Grand Opening? Contact us at marketing@priorityonevitamins.com – we’d love to support your events by providing samples and the option to send a Priority One representative to join you.